• Acetaminophen suppositories are taken rectally, usually every four to six hours as needed (depending on the exact dosage). Do not take acetaminophen suppositories by mouth.
   
• Be sure to remove to foil wrapper before use. Try not to handle the suppository too much, as your body heat will start to melt it.
   
• Carefully insert the unwrapped suppository into the rectum. For young children, it may be helpful to hold the buttocks together for 30 to 60 seconds after insertion.
   
• Try not to have a bowel movement right after using an acetaminophen suppository.
   
• It is important to keep track of how much acetaminophen is given, as it is easy to give too much (see Tylenol Poisoning). It is important to remember that acetaminophen is found in many medications (both prescription and non-prescription).
   
• For the medication to work properly, it must be taken as prescribed.
   

• Your age
• Other medications you may be taking
• Other medical conditions you may have.