Adacel Drug Interactions

A number of medications may interfere with the "booster" vaccine Adacel. Problems may occur if the vaccine is combined with immunosuppressant medicines, tetanus immune globulin, or other vaccines. Drug interactions with Adacel may reduce the effectiveness of the vaccination, so it is best to avoid taking immunosuppresants or getting other vaccines if you are receiving Adacel.

An Overview of Adacel Drug Interactions

Adacel® (Tdap vaccine) can potentially interact with a few medications or other vaccines. Some of the medicines or vaccines that may lead to drug interactions with Adacel include:
 
  • Immunosuppressants, such as:

 

 

    • Certain monoclonal antibodies, including:

 

  

    • Chemotherapy (as well as radiation treatment)

 

    • Corticosteroids, such as:

 

      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)

 

    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Etanercept (Enbrel®)
    • Methotrexate (Rheumatrex®)
    • Mycophenolate (CellCept®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)

 

  • Other vaccines
  • Tetanus immune globulin.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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