Drug Interactions With Amoxicillin/Clavulanate Potassium ES
Allopurinol (Aloprim, Zyloprim)
Combining allopurinol with antibiotics similar to amoxicillin/clavulanate potassium ES increases the risk of skin rashes. It is not known if this is also true with amoxicillin/clavulanate potassium ES.
Methotrexate (Rheumatrex, Trexall)
Penicillin-type antibiotics (including amoxicillin/clavulanate potassium ES) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate. Your healthcare provider may need to monitor you more closely.
Amoxicillin/clavulanate potassium ES may decrease the effectiveness of mycophenolate mofetil. Check with your healthcare provider before taking these two medications together.
Despite the longstanding belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether you should use a backup method of birth control.
Oral Typhoid Vaccine
Amoxicillin/clavulanate potassium ES may decrease the effectiveness of the oral typhoid vaccine. If you are taking amoxicillin/clavulanate potassium ES, your oral typhoid vaccine may need to be postponed for at least a day after stopping the antibiotic.
Probenecid can decrease the body's ability to remove amoxicillin/clavulanate potassium ES from the blood, potentially leading to high amoxicillin/clavulanate potassium ES blood levels. Talk with your healthcare provider before taking these medications together.