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Side Effects of Amoxicillin/Clavulanate Potassium ES

Although most people tolerate amoxicillin/clavulanate potassium ES well, this antibiotic can cause side effects. When this drug was studied in clinical trials, some of the most commonly reported problems included diarrhea, vomiting, and diaper rash. If your child develops any serious side effects during treatment (such as bloody diarrhea or difficulty breathing), contact your healthcare provider right away.

An Introduction to Side Effects of Amoxicillin/Clavulanate Potassium ES

As with any medicine, amoxicillin/clavulanate potassium ES (Augmentin ES®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with amoxicillin/clavulanate potassium ES. Your healthcare provider can discuss a more complete list with you.)

Side Effects to Report

There are a number of possible side effects with amoxicillin/clavulanate potassium ES that you should report to your healthcare provider. These include but are not limited to:
  • Signs of liver problems (which occur very rarely), such as:
    • Yellow eyes
    • Yellow skin (jaundice)
    • Very dark urine (although amoxicillin/clavulanate potassium ES can cause a harmless discoloration of urine)
    • Upper-right abdominal pain (stomach pain)
  • Very severe, bloody, or watery diarrhea


  • Any diarrhea that lasts for more than two or three days (mild, temporary diarrhea is common and is not usually a cause for concern)
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Wheezing
    • Swelling of the mouth or throat
    • Difficulty breathing.
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Amoxicillin/Clavulanate Potassium ES Information

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