Children's Tylenol Drug Interactions

If your child is taking carbamazepine, phenobarbital, or over-the-counter cold or cough medicines in combination with Children's Tylenol, drug interactions may occur. Some of these interactions can make both drugs less effective and more toxic, while others may increase the risk of liver damage. To help prevent Children's Tylenol interactions, be sure to consult your child's healthcare provider before giving your child any other medications.

 

Children's Tylenol Drug Interactions: An Overview

Children's Tylenol® (children's acetaminophen) can potentially interact with several other medications. However, many of these medications are not usually used in children. Some of the medicines that are used in children that may lead to Children's Tylenol interactions include:
 
  • Carbamazepine (Carbatrol®, Epitol™, Equetro®, Tegretol®)
  • Codeine and acetaminophen (Capital® and Codeine, Phenco-Care™, Tylagesic™, Tylenol No. 3, Tylenol No. 4)
  • Isoniazid (Nydrazid®)
  • Phenobarbital (Luminal®)
  • Several non-prescription cough, cold, flu, and allergy products
  • Warfarin (Coumadin®, Jantoven®).
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(For a more complete list of medications that interact with Tylenol, including medications that are not likely to be taken by children, see Tylenol Drug Interactions.)
 

Children's Tylenol Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Children's Tylenol is combined with any of the drugs listed above.
 
Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
Carbamazepine can affect the way the body handles Children's Tylenol, making both drugs more toxic and less effective. Talk to your child's healthcare provider about using Children's Tylenol in children who take carbamazepine.
(Children's Tylenol Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;