Drug Interactions With Clonidine ER
Drug Interactions With Clonidine ER ExplainedThe following sections explain in detail the potentially negative reactions that can occur when clonidine ER is combined with any of the drugs listed above.
Combining clonidine ER with a beta blocker may increase the risk for dangerously low blood pressure (hypotension) or a dangerously slow heart rate (bradycardia). However, in many cases, such combinations are considered safe and effective. Check with your healthcare provider before combining these medications.
If you take both clonidine ER and a beta blocker, stopping clonidine ER (without stopping the beta blocker) could increase the risk for dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking the beta blocker several days before you gradually reduce the dose of clonidine ER. Do not attempt this without the approval and supervision of your healthcare provider.
Certain Calcium Channel Blockers
Combining clonidine ER with certain calcium channel blockers may cause dangerously low blood pressure and a slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together.
Combining clonidine ER with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together.
Other Medications That Cause Drowsiness
Clonidine ER should be used with caution when combined with other sedating medications or substances. Check with your healthcare provider before taking such medications together. Additionally, many antidepressants may decrease the effectiveness of clonidine ER for lowering blood pressure.