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Side Effects of Clonidine ER

Common Side Effects

Clonidine ER has been studied extensively in clinical trials. In these studies, one group of people received clonidine ER, while another group was given a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
Some studies combined clonidine ER with a stimulant medication (such as Ritalin®); the information in this article does not include side-effect data from such trials, as it is difficult to know how much each medication contributed to the side effects.
In clinical studies, the most common side effects of clonidine ER included:
  • Drowsiness -- in up to 31 percent of people
  • Headaches -- up to 29 percent
  • Upper abdominal pain (stomach pain) -- up to 20 percent
  • Fatigue -- up to 16 percent
  • Upper respiratory tract infections (such as the common cold) -- up to 11 percent
  • Irritability -- up to 9 percent
  • Nightmares -- up to 9 percent
  • Dizziness -- up to 7 percent
  • A gastrointestinal virus (the so-called "stomach flu") -- up to 7 percent
  • Throat pain -- up to 6 percent
  • Nausea -- up to 6 percent.
Other common clonidine ER side effects, occurring in 3 to 6 percent of people, included but were not limited to:
  • Emotional problems
  • Constipation
  • Dry mouth
  • Nasal congestion
  • Increased body temperature
  • Ear pain
  • Abnormal sleep
  • Aggression
  • Asthma
  • A slow heart rate or a fast heart rate
  • Bedwetting
  • Frequent daytime urination
  • Flu-like sickness
  • Tearfulness
  • Thirst
  • Shakiness (tremors)
  • Nosebleed
  • Sleep terrors
A Dose of Reassurance for Parents of Picky Eaters

Clonidine ER Drug Information

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