Comvax Drug Interactions

A number of drugs can interact with Comvax, including cortisone, heparin, and chemotherapy. Children who take immunosuppressants may not get the full benefit of the vaccine, as the immune system may not be fully capable of responding to Comvax. Before your child receives this vaccination, talk to his or her healthcare provider about any potential drug interactions.

An Overview of Interactions With Comvax

Comvax® (Hib vaccine and hepatitis B vaccine) can potentially interact with a few medications. Some of the medicines that may lead to drug interactions with Comvax include:
 
 
 
    • Chemotherapy and radiation treatment
    • Corticosteroids, such as:
 
      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)
 
    • Cyclophosphamide (Cytoxan®)
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Etanercept (Enbrel®)
    • Methotrexate (Rheumatrex®)
    • Mycophenolate (CellCept®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®).
 
(Comvax Drug Interactions Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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