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Drug Interactions With Imipramine Hydrochloride

Barbiturates
Taking imipramine and barbiturates together can increase the risk of side effects of both drugs (such as drowsiness or dizziness). Also, barbiturates may decrease the level of imipramine in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
 
Blood Pressure Medications
Imipramine can make certain blood pressure mediations, such as clonidine (Catapres®), less effective. Also, taking it with high blood pressure medications may increase your chance of low blood pressure (hypotension). Talk with your healthcare provider before taking these medications together.
 
Buspirone (BuSpar)
Because combining imipramine hydrochloride with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine
Taking imipramine with cimetidine can increase the level of imipramine in your blood, possibly increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
 
Fentanyl
Combining imipramine hydrochloride with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking imipramine hydrochloride with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining imipramine hydrochloride with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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