Drug Interactions With Imipramine Hydrochloride

In order to minimize drug interactions with imipramine hydrochloride, tell your healthcare provider if you are taking other medications before starting the antidepressant. Drugs that may lead to interactions include anticholinergic medications, barbiturates, blood pressure medications, and cimetidine. These drug interactions with imipramine hydrochloride can alter medicine levels in your blood and increase the risk for side effects.

 

Drug Interactions With Imipramine Hydrochloride: An Introduction

Imipramine hydrochloride (Tofranil®) can potentially interact with many medicines. Some of the medicines that may lead to drug interactions with imipramine hydrochloride include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®)
  • Thyroid medications, including:
o Liothyronine (Cytomel®)
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®)
(Drug Interactions With Imipramine Hydrochloride Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;