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Drug Interactions With Imipramine Hydrochloride
In order to minimize drug interactions with imipramine hydrochloride, tell your healthcare provider if you are taking other medications before starting the antidepressant. Drugs that may lead to interactions include anticholinergic medications, barbiturates, blood pressure medications, and cimetidine. These drug interactions with imipramine hydrochloride can alter medicine levels in your blood and increase the risk for side effects.
Imipramine hydrochloride (Tofranil®) can potentially interact with many medicines. Some of the medicines that may lead to drug interactions with imipramine hydrochloride include:
- Alcohol
- Anticholinergic medications, including:
- Atropine
- Belladonna (Donnatal®, B&O Supprettes®)
- Benztropine (Cogentin®)
- Clidinium (Librax®)
- Clozapine (Clozaril®)
- Darifenacin (Enablex®)
- Dicyclomine (Bentyl®)
- Diphenhydramine (Benadryl®, Tylenol PM®)
- Glycopyrrolate (Robinul®)
- Haloperidol (Haldol®)
- Homatropine (Hycodan®)
- Hyoscyamine (Levsin®)
- Ipratropium (Atrovent®)
- Scopolamine (Transderm Scop®)
- Tiotropium (Spiriva®)
- Tolterodine (Detrol®)
- Trospium (Sanctura®)
- Arrhythmia medications, including:
- Amiodarone (Cordarone®)
- Disopyramide (Norpace®)
- Dofetilide (Tikosyn®)
- Flecainide (Tambocor®)
- Ibutilide (Corvert®)
- Propafenone (Rythmol®)
- Quinidine
- Sotalol (Betapace®)
- Barbiturates, including:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Blood pressure medications
- Buspirone (BuSpar®)
- Cimetidine (Tagamet®)
- Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®)
- Intravenous methylene blue
- Linezolid (Zyvox®)
- Lithium (Eskalith®, Lithobid®)
- Methylphenidate (Concerta®, Daytrana®, Metadate CD®, Metadate ER®, Methylin®, Ritalin®, Ritalin LA®, Ritalin SR®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Phenothiazine medications, including:
- Phenytoin (Dilantin®)
- Pressors, including:
- Dopamine (Intropin®)
- Dobutamine (Dobutrex®)
- Epinephrine (Adrenalin®, EpiPen®)
- Norepinephrine (Levophed®)
- SSRI or SNRI medications, such as:
- Citalopram (Celexa®)
- Desvenlafaxine (Pristiq®)
- Duloxetine (Cymbalta®)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Fluvoxamine (Luvox®, Luvox CR®)
- Milnacipran (Savella™)
- Paroxetine (Paxil®, Paxil CR®, Pexeva®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- St. John’s wort
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®)
- Thyroid medications, including:
- Liothyronine (Cytomel®)
- Liotrix (Thyrolar®)
- Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Tirosint®, Unithroid®)
- Thyroid (Armour® Thyroid, Nature-Throid®)
- Other tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Triptans, including:
- Almotriptan (Axert®)
- Eletriptan (Relpax®)
- Frovatriptan (Frova®)
- Naratriptan (Amerge®)
- Rizatriptan (Maxalt®)
- Sumatriptan (Alsuma™, Imitrex®, Sumavel™, Zecuity™) or sumatriptan/naproxen sodium (Treximet™)
- Zolmitriptan (Zomig®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD