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Imipramine Hydrochloride Dosing

Imipramine Hydrochloride Dosing for Bedwetting

The recommended starting dose when treating bedwetting in children is imipramine 25 mg, taken one hour before bedtime. If the medication does not work within one week, your healthcare provider may recommend increasing the dose up to imipramine 50 mg (for children under 12) or imipramine 75 mg (for children over 12). For children who have problems with early nighttime bedwetting, your healthcare provider may recommend taking imipramine in the mid-afternoon and at bedtime. When stopping the medication, the dose should be reduced gradually, as this may help prevent a replapse of bedwetting.
It is important that your child's dose of imipramine not exceed more than 1.1 mg per pound per day, as higher doses may put your child at increased risk for an irregular heart rhythm (arrhythmia).
If your child misses a dose of imipramine, skip the missed dose. Do not try to make up for a bedtime dose by giving it during the day.

General Information on Dosing With Imipramine Hydrochloride

Considerations for people taking imipramine include the following:
  • Imipramine should be taken at the same time(s) each day.
  • Your dosage can be taken with or without food. If it upsets your stomach, try taking it with food.
  • If you are experiencing bothersome drowsiness or dizziness with imipramine, ask your healthcare provider about taking your dose at bedtime instead of during the day. This may help decrease these side effects.
  • It can take several weeks to see the full effects of imipramine on depression. Try to give the medication a chance to work before becoming discouraged.
  • For imipramine to work properly, you have to take it as prescribed. The medicine will not work if you take it differently from how your healthcare provider recommends.
  • If you are unsure about anything related to imipramine hydrochloride dosing, talk to your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider. Stopping the medicine abruptly may increase the risk for withdrawal symptoms (see Imipramine Withdrawal).
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Imipramine HCl

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