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Increlex and Pregnancy

As a pregnancy Category C medication, Increlex (mecasermin) may not be safe for use in pregnant women. Animal studies suggest that this drug may increase the risk for miscarriages or other problems. You should not take this medicine while pregnant unless the benefits outweigh the risks.


Can Pregnant Women Use Increlex?

Increlex® (mecasermin) is a prescription medication used in the treatment of certain children who are very short for their age because their bodies do not make enough of a hormone known as insulin-like growth factor-1 (IGF-1). Based on the results of animal studies, this medication may not be safe for use during pregnancy.

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Increlex is classified as a pregnancy Category C medicine.
Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Increlex has not been studied in pregnant women. In animal studies, the drug did not cause birth defects when given to pregnant rats and rabbits, even in high doses. It did, however, increase the risk for miscarriage in the pregnant rabbits.
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh any possible risks to her unborn child.

Final Thoughts

If you are pregnant or thinking about becoming pregnant while taking Increlex, let your healthcare provider know. He or she will consider both the benefits and risks before making a recommendation in your particular situation.
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