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Increlex Uses

How Does This Medicine Work?

Increlex is a laboratory-made version of insulin-like growth factor-1 (IGF-1) hormone, and has the same actions in the body as natural IGF-1. When injected, it works to replace IGF-1 in children who have low levels of the hormone in their body.
 
Increlex is made in a laboratory setting using "recombinant DNA technology." This technology is the process of combining two different strands of DNA. Increlex is made by adding a gene (a sequence of DNA) for human IGF-1 to bacteria (specifically E. coli) so the bacteria make the hormone.
 

Is It Safe for Children to Use Increlex?

This drug is approved for use in children as young as two years old. It has not been adequately studied in children under the age of two. Talk with your child's healthcare provider about the particular benefits and risks of using Increlex in very young children.
 

Can Older Adults Use It?

Increlex is approved for children age 2 to 18 years. It has not been adequately studied for use in adults, especially adults over the age of 65 years. 
 

Off-Label Uses for Increlex

On occasion, your healthcare provider may recommend this medication for something other than the uses discussed in this article. This is known as an "off-label" use. Increlex has been studied for the off-label treatment of adults with the following conditions:
   
However, evidence to support its use in these conditions is inconclusive at this time.
 
It is possible that Increlex could be prescribed off-label to treat children with mild-to-moderate primary IGF-1 deficiency (instead of severe primary IGF-1 deficiency) or short stature due to other causes.
 
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Increlex Medication Information

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