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Drug Interactions With IPV
Immunosuppressants and anticoagulants may react negatively with IPV. Caution should be used when giving intramuscular injections to people taking anticoagulants. Also, the vaccine may not be as effective for people taking immunosuppressants. To help limit these drug interactions with IPV, tell your healthcare provider about all medications you are taking and any medical conditions you have before getting vaccinated.
An Overview of Interactions With IPV
IPV (inactivated polio vaccine) can potentially interact with a few medications. It does not interact with other standard childhood vaccines and can be given at the same time. Some of the medicines that may lead to IPV drug interactions include:
- Anticoagulant medications, such as warfarin (Coumadin®, Jantoven®) or heparin
- Immunosuppressants, such as:
- Azathioprine (Imuran®)
- Certain biologic medications, such as:
- Abatacept (Orencia®)
- Adalimumab (Humira®)
- Alefacept (Amevive®)
- Alemtuzumab (Campath®)
- Anakinra (Kineret™)
- Basiliximab (Simulect®)
- Canakinumab (Ilaris®)
- Certolizumab pegol (Cimzia®)
- Daclizumab (Zenapax®)
- Eculizumab (Soliris®)
- Efalizumab (Raptiva®)
- Etanercept (Enbrel®)
- Gemtuzumab ozogamicin (Mylotarg®)
- Glatiramer (Copaxone®)
- Golimumab (Simponi™)
- Infliximab (Remicade®)
- Ibritumomab (Zevalin®)
- Muromonab-CD3 (Orthoclone OKT®)
- Natalizumab (Tysabri®)
- Ofatumumab (Arzerra™)
- Rilonacept (Arcalyst™)
- Rituximab (Rituxan®)
- Tositumomab (Bexxar®)
- Ustekinumab (Stelara™)
- Chemotherapy (as well as radiation treatment)
- Corticosteroids, such as:
- Betamethasone (Celestone®)
- Cortisone
- Dexamethasone (Decadron®)
- Fludrocortisone (Florinef®)
- Hydrocortisone (Cortef®)
- Methylprednisolone (Depo-Medrol®, Medrol®)
- Prednisolone (Pediapred®)
- Prednisone
- Triamcinolone (Kenalog®)
- Cyclophosphamide (Cytoxan®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Methotrexate (Rheumatrex®)
- Mycophenolate (CellCept®)
- Sirolimus (Rapamune®)
- Tacrolimus (Prograf®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD