Drug Interactions With Isotretinoin
The following sections explain in detail the potentially negative interactions that can occur when isotretinoin is combined with any of the drugs listed above.
There have been cases of pseudotumor cerebri (a certain type of high blood pressure in the cranium) in people who took isotretinoin in combination with certain antibiotics. It is best to avoid taking these medications together.
Taking isotretinoin in combination with corticosteroids may increase the risk of osteoporosis. This interaction probably applies only to corticosteroids taken by injection or by mouth, not those inhaled or used as a nasal spray.
Combining phenytoin with isotretinoin might increase the risk of osteoporosis. Check with your healthcare provider before taking these medications together.
Progestin-Only Birth Control Pills
Women of childbearing potential must use two forms of birth control while taking isotretinoin (as well as one month before and one month after using this acne medication). Progestin-only birth control pills are probably not effective enough for women to use while taking isotretinoin (they are significantly less effective than combined oral contraceptives that contain an estrogen and a progestin).
St. John's Wort
Do not self-treat yourself with St. John's wort while taking isotretinoin. If you have depression, you need to be evaluated by your healthcare provider. Also, St. John's wort can make birth control pills less effective, a problem that would be especially dangerous for women taking isotretinoin, as this medication causes birth defects.
Isotretinoin is related to vitamin A. Do not take vitamin A while on this medication, as this could cause additive toxic effects.