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Drug Interactions With Isotretinoin

Several medicines may cause negative drug interactions with isotretinoin, including certain antibiotics, corticosteroids, and progestin-only birth control pills. These interactions can increase your risk for certain health conditions, such as osteoporosis or pseudotumor cerebri. If drug interactions with isotretinoin are a concern, make sure to talk to your healthcare provider before starting any other medications.

An Overview of Drug Interactions With Isotretinoin

Isotretinoin (Accutane®, Absorica™, Amnesteem™, Claravis™, Sotret®) can potentially interact with several other medications. Some of the medicines that may lead to isotretinoin drug interactions include:
  • Certain antibiotics, such as:
  • Corticosteroids, such as:


    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
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Isotretinoin for Acne

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