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Isotretinoin Dosage

When determining your isotretinoin dosage, your healthcare provider will consider factors such as the severity of your acne, your weight, and how you respond to the drug. In general, the recommended dose of isotretinoin is 0.5 mg to 1 mg per kg of body weight each day, divided into two daily doses. Most people only need one 15- to 20-week course to effectively treat acne.

An Introduction to Isotretinoin Dosages

The dose of isotretinoin (Accutane®, Absorica™, Amnesteem™, Claravis™, Sotret®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The severity of your acne
  • Your weight
  • How you respond to the medication.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Dose of Isotretinoin for Acne

In most cases, the recommended isotretinoin dosage is 0.5 mg to 1 mg per kg of body weight (about 0.23 mg to 0.45 mg per pound) each day, divided into two daily doses. For adults with severe acne or acne limited mostly to the trunk of the body, a dose of 2 mg per kg (about 0.91 mg per pound) each day, divided into two daily doses, may be necessary. Your healthcare provider may adjust your dose as necessary, especially if you develop bothersome side effects of isotretinoin.
Typically, isotretinoin is taken for 15 to 20 weeks. Your acne will continue to improve after you stop taking the medication. A second course may be recommended if your acne is still a problem eight weeks after finishing the first course.
You will not be able to get more than a 30-day supply of isotretinoin at a time. Each time you need more, you will need a new prescription and new authorization from the iPLEDGE program (the program designed to prevent birth defects caused by isotretinoin). If you are a woman of childbearing potential, you will need to have a negative pregnancy test every month (done by a laboratory) and must use two different forms of birth control.
A Dose of Reassurance for Parents of Picky Eaters

Isotretinoin for Acne

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