Lupron^® (leuprolide acetate) is not likely to react with most medications. However, there are a few potential drug interactions that may occur if Lupron is taken with medications used to treat diabetes, including:

Alpha-glucosidase inhibitors, such as:

- Acarbose (Precose^®)
- Miglitol (Glyset^®)

Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as:

- Alogliptin (Nesina^®), alogliptin and metformin (Kazano^®), and alogliptin and pioglitazone (Oseni^®)
- Linagliptin (Tradjenta™)
- Linagliptin and metformin (Jentadueto™)
- Saxagliptin (Onglyza™)
- Sitagliptin (Januvia^®)
- Sitagliptin and metformin (Janumet^®)
- Sitagliptin and metformin XR (Janumet^® XR)

Glitazones and glitazone combination medications, such as:

- Pioglitazone hydrochloride (Actos^®)
- Pioglitazone and glimepiride (Duetact^®)
- Pioglitazone and metformin (Actoplus Met^®)
- Pioglitazone and metformin XR (Actoplus Met^® XR)
- Rosiglitazone (Avandia^®)
- Rosiglitazone and glimepiride (Avandaryl^®)
- Rosiglitazone and metformin (Avandamet^®)

Glucagon-like peptide 1 receptor agonists, such as:

- Exenatide (Byetta^®)
- Liraglutide (Victoza^®)

Insulin of any type
Meglitinides, such as:

- Nateglinide (Starlix^®)
- Repaglinide (Prandin^®)

Metformin (Glucophage^®, Glucophage XR^®, Fortamet^®, Glumetza^®, Riomet^®)
Sulfonylureas (or sulfonylurea combination medications), such as:

- Chlorpropamide (Diabinese^®)
- Glimepiride (Amaryl^®)
- Glimepiride and pioglitazone (Duetact^®)
- Glimepiride and rosiglitazone (Avandaryl^®)
- Glipizide (Glucotrol^®, Glucotrol XL^®)
- Glipizide and metformin (Metaglip^®)
- Glyburide (DiaBeta^®, Micronase^®, Glynase^®)
- Glyburide and metformin (Glucovance^®)
- Tolazamide (Tolinase^®)
- Tolbutamide (Orinase^®).

Lupron Drug Interactions Article Continues on Next Page >

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List of references (click here)

Written by/reviewed by: Susan Lakey, PharmD, MPH

Last reviewed by: Kristi Monson, PharmD

Lupron Drug Interactions

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Generic Lupron

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