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Lupron Warnings and Precautions

Specific Precautions and Warnings With Lupron

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • When you first start using Lupron, the levels of sex hormones in your body will increase before they decrease. This may cause an increase in symptoms in the initial weeks of treatment, which could include worsening bone pain and difficulty urinating in men with prostate cancer, and increased signs of puberty in children. Contact your healthcare provider if these symptoms do not go away within the first few weeks of treatment, or if they are severe or bothersome.
  • If you are using Lupron for relieving prostate cancer symptoms and the cancer has spread to your spine or urinary tract, your healthcare provider may choose to monitor you more closely in the first few weeks of treatment when your hormone levels are high. You may be at an increased risk for potentially serious problems, such as urinary tract blockage or pressure in the spine, which could lead to paralysis and even death.
  • Your healthcare provider may monitor your hormone levels with blood tests to make sure the medication is working to treat your condition. You may also need monitoring to check for potential side effects. Make sure to keep all of your appointments with your healthcare provider.
  • The Lupron injection contains benzyl alcohol. People with an allergy to benzyl alcohol may experience a reaction at the injection site, such as redness and hardening of the skin tissue. While some people may experience redness, itching, swelling, or burning at the injection site, be sure to tell your healthcare provider if these symptoms are severe or do not go away.
  • Lupron may decrease bone density, which could increase the risk for osteoporosis and bone fractures. This side effect may be especially concerning for people who already have osteoporosis or who have risk factors for this disease, including those who regularly use alcohol or tobacco or who have a family history of osteoporosis.
  • In rare cases, Lupron may cause a condition known as pituitary apoplexy, which occurs when tissue of the pituitary gland becomes damaged and dies, leading to pituitary gland failure. Seek immediate medical attention if you develop any signs or symptoms of pituitary apoplexy, such as:
    • A sudden, severe headache
    • Weakness of the muscles that control eye movement
    • Changes in vision
    • Low blood pressure
    • Confusion.
  • It is important that children with central precocious puberty use this medicine as prescribed. Missing doses can result in a return of puberty.
  • Contact your child's healthcare provider if you notice mood or behavioral changes in your child during treatment with Lupron. Also, make sure to report any continued signs of puberty, including menstrual bleeding or spotting in girls beyond the first two months of treatment.
  • Lupron has been reported to cause high blood sugar levels and an increased risk for developing diabetes. It may also worsen blood glucose control in people with preexisting diabetes. Your healthcare provider may periodically monitor your blood sugar levels to see if you are developing diabetes, or have you check your blood sugar levels more often if you already have diabetes.
  • Lupron has been reported to cause a stroke, heart attack, and sudden cardiac death. Make sure your healthcare provider knows your complete medical history before you start Lupron, so he or she can determine your underlying risk for these problems.
  • It is unknown if Lupron passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Lupron and Breastfeeding).
  • Lupron is a pregnancy Category X medication. This means it should not be used in pregnant women (see Lupron and Pregnancy).
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