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A number of medications may interfere with the "booster" vaccine Adacel. Problems may occur if the vaccine is combined with immunosuppressant medicines, tetanus immune globulin, or other vaccines. Drug interactions with Adacel may reduce the effectiveness of the vaccination, so it is best to avoid taking immunosuppressants or getting other vaccines if you are receiving Adacel.

An Overview of Adacel Drug Interactions

Adacel® (Tdap vaccine) can potentially interact with a few medications or other vaccines. Some of the medicines or vaccines that may lead to drug interactions with Adacel include:
  • Immunosuppressants, such as:



    • Certain biologic medications, such as:


    • Chemotherapy (as well as radiation treatment)


    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)



  • Other vaccines
  • Tetanus immune globulin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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