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Injection site reactions (including pain, redness, and swelling) and fever are the most common side effects that have been reported with Adacel. Problems due to the vaccine are often mild and do not require medical attention in most cases. Certain side effects are potentially serious, however, and should be reported to your healthcare provider immediately, including severe shoulder pain, weakness, or behavior changes.

An Introduction to Adacel Side Effects

As with all vaccines, side effects are possible with Adacel® (Tdap vaccine). However, not everyone who receives the vaccine will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Adacel. Your healthcare provider can discuss a more complete list of Adacel side effects with you.)

Common Side Effects of Adacel

Adacel has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people who received Adacel were documented and compared to side effects that occurred in a similar group of people who were given a similar vaccine that did not have the pertussis component (the traditional "Td" vaccine that has been given to adults for years).
This way, it is possible to see what side effects occurred, how often they appeared, and how they compare to the group given the Td vaccine. In these studies, the most common Adacel side effects included:
  • Injection site pain -- in up to 77.8 percent of people
  • Injection site redness -- up to 24.7 percent
  • Injection site swelling -- up to 21 percent
  • Fever -- up to 5 percent.
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Last reviewed by: Kristi Monson, PharmD;
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