Kids Home > Pentacel Side Effects

Fussiness or irritability, inconsolable crying, and lethargy are the most common side effects that have been reported with Pentacel. Side effects of the vaccine are often mild and do not require medical attention in most cases. However, there are some rare but serious side effects that should be reported to a healthcare provider immediately (such as weakness or high fever).

An Introduction to Pentacel Side Effects

As with all vaccines, side effects are possible with Pentacel® (DTaP, inactivated polio vaccine, and Hib vaccine). However, not everyone who receives the vaccine will have problems. In fact, most children tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Pentacel. Your healthcare provider can discuss a more complete list of Pentacel side effects with you.)

Common Side Effects of Pentacel

Pentacel has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of children given Pentacel (a combination of multiple vaccines) were documented and compared to side effects that occurred in a similar group of children given some or all of the same vaccines separately (at the same time but not in the same injection).
This way, it is possible to see what side effects occurred, how often they appeared, and how they compare to the group receiving the vaccines separately.
In these studies, the most common Pentacel side effects included:
  • Fussiness or irritability -- in up to 76.9 percent of children
  • Inconsolable crying -- up to 59.3 percent
  • Lethargy -- up to 45.8 percent
  • Fever -- up to 16.3 percent
  • Tenderness at the injection site -- up to 56.1 percent
  • Swelling at the injection site -- up to 9.7 percent
  • Redness at the injection site -- up to 17.3 percent.
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Last reviewed by: Kristi Monson, PharmD;
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