Kids Home > Side Effects of the Pneumococcal Conjugate Vaccine

Although most children respond well to the pneumococcal conjugate vaccine, side effects are possible. Common side effects that have been reported with the vaccine include diarrhea, drowsiness, and decreased appetite. Most side effects of the vaccine are minor, but you should seek medical attention immediately if your child develops a high fever, seizures, or unusual behavior changes.

An Introduction to Pneumococcal Conjugate Vaccine Side Effects

As with all vaccines, side effects are possible with the pneumococcal conjugate vaccine (Prevnar 13®). However, not everyone who receives the vaccine will have problems. In fact, most children tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with this product. Your healthcare provider can discuss a more complete list of pneumococcal conjugate vaccine side effects with you.)

Serious Side Effects Seen With Pneumococcal Conjugate Vaccine

There are a number of rare but serious side effects with pneumococcal conjugate vaccine that you should report to your child's healthcare provider. These include, but are not limited to:
  • A high fever
  • Any unusual behavior changes (aside from the usual fussiness that typically occurs after vaccinations)
  • Seizures
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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