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If you are pregnant, Vigamox (moxifloxacin eye drops) can be prescribed if the benefits outweigh the risk. This drug is unlikely to cause problems during pregnancy, since very little of it actually reaches the bloodstream. Negative effects have been reported in animal studies; however, it's important to note that the doses used in these studies were more than 20,000 times the equivalent human dose.
Is Vigamox Safe During Pregnancy?
Vigamox® (moxifloxacin eye drops) is a prescription antibiotic medication approved to treat bacterial conjunctivitis (bacterial "pink eye"). Animal studies have shown that extremely high doses of the active ingredient in Vigamox might increase the risk of certain problems during pregnancy, although the low Vigamox dosage used in humans is unlikely to cause such problems.
What Is Pregnancy Category C?
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is used during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans, but do appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
When large doses of moxifloxacin (the active ingredient in Vigamox) were given to pregnant rats, the medication did not cause birth defects. However, extremely large doses given to pregnant rats increased the risk of fetal death, low fetal weight, and slightly delayed bone development. In rabbits, the drug increased the risk of rib and vertebral defects. In monkeys, moxifloxacin increased the risk of smaller fetuses.
It is important to understand that the animal studies used exceptionally large doses of moxifloxacin -- up to 21,700 times the equivalent human dosage with the eye drops. Because very little Vigamox reaches the bloodstream, it is unlikely that the problems seen in animal studies would occur with normal use of this medication.
A pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.