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Pentacel Drug Interactions

A number of medications may cause drug interactions with Pentacel, including anticoagulant medicines and various immunosuppressants (such as azathioprine, corticosteroids, and chemotherapy or radiation therapy). These drug interactions could reduce the effectiveness of the vaccine or lead to potentially serious complications.

An Overview of Pentacel Interactions

Pentacel® (DTaP, inactivated polio vaccine, and Hib vaccine) can potentially interact with a few medications. Some of the medicines that may lead to interactions with Pentacel include:


    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)



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Pentacel Vaccine Information

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