Drug Interactions With Pimecrolimus
More Detail on Drug Interactions With PimecrolimusThe following sections explain in detail the potentially negative interactions that can occur when pimecrolimus is combined with any of the drugs listed above.
People who use pimecrolimus may experience facial flushing (a sudden redness and warmth of the skin) after consuming alcohol. Talk to your healthcare provider if facial flushing becomes a problem for you. He or she may be able to recommend ways to reduce the flushing effects, such as taking low-dose aspirin.
CYP 3A4 Inhibitor Medications
The liver breaks down pimecrolimus using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining pimecrolimus with one of these drugs may increase the level of pimecrolimus in your body, potentially increasing your risk for side effects. The risk for this interaction is generally low, as only a small amount of pimecrolimus is expected to be absorbed into the bloodstream after normal use. However, some people may absorb more pimecrolimus than expected.
It is generally recommended that people taking other immunosuppressant medications not use pimecrolimus, due to the increased risk for infections, lymphoma (cancer of the lymph nodes), and skin cancer. The risk for these side effects is greater with higher immunosuppressant doses and long-term immunosuppressant use. Talk to your healthcare provider before using pimecrolimus with another immunosuppressant medicine.