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ProQuad Drug Interactions

ProQuad Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when ProQuad is combined with any of the drugs listed above.
Immune Globulins or Blood Products
Immune globulins or blood products may decrease the effectiveness of live vaccines like ProQuad. Vaccination with ProQuad should be postponed for three months or more after a dose of immune globulin or after receiving a blood product.
If you are taking an immunosuppressant, you may not receive the full benefit of ProQuad. More importantly, with live vaccines such as ProQuad, people taking immunosuppressants may have a higher risk of actually developing the infection from the vaccine, albeit a usually mild form. In many situations, this vaccine may not be recommended for people taking immunosuppressants. Your healthcare provider will evaluate your individual situation before making a recommendation.
People should avoid taking any salicylates (including aspirin) for six weeks after receiving ProQuad, due to the potential risk of Reye's syndrome (a potentially fatal condition). This drug interaction is theoretical, based on cases of Reye's syndrome seen when people with chickenpox took aspirin (ProQuad contains a chickenpox vaccine).
Tuberculin Skin Tests
Live vaccines like ProQuad may interfere with the accuracy of tuberculin skin tests, which are used to screen for tuberculosis, perhaps increasing the risk of false-negative results. Therefore, you should wait at least four to six weeks after receiving the ProQuad vaccine before having a tuberculin skin test. However, it is safe to get the tuberculin skin test before or at the same time as the vaccine.
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