ProQuad is a vaccine designed to protect against chickenpox, measles, mumps, and rubella. It is administered on two separate occasions: once at 12 to 15 months of age and then again at 4 to 6 years old. Using ProQuad in individuals over the age of 12 is considered an off-label (unapproved) use of this vaccine.
What Is ProQuad Used For?ProQuad® (MMRV) is a childhood vaccine that protects against the following four viral diseases:
- Chickenpox (varicella)
- Measles, a viral infection that commonly causes a rash, fever, cough, runny nose, and eye irritation. Serious complications of measles include:
- Mumps, a viral infection that commonly causes a fever, headache, and swollen glands. Serious complications of mumps include:
- Meningitis (a dangerous infection of the lining of the brain and spinal cord)
- Swelling of the ovaries and testicles
- Rubella (also known as German measles), a viral infection that commonly causes a rash, fever, and arthritis. This infection can also cause serious complications for pregnant women, such as:
- Serious birth defects.
ProQuad can be used instead of giving the two individual vaccines (the MMR and the varicella vaccine) separately. Typically, the first dose would be given at 12 to 15 months of age, and the second dose would be given before starting school (4 to 6 years of age).
However, studies have suggested that ProQuad is more likely to cause fevers and febrile seizures (seizures associated with high fevers) in children age 12 to 23 months old, compared to giving the MMR and varicella vaccines as separate injections at the same visit.
Therefore, the Centers for Disease Control (CDC) suggests that the MMR and varicella vaccines be given separately for children age 12 to 23 months of age, unless parents prefer to use ProQuad. The main reason that a parent would prefer ProQuad would be to reduce the number of injections that are necessary.