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ProQuad Vaccine Side Effects

Some of the most commonly reported side effects of ProQuad include reactions at the injection site, such as pain, tenderness, and redness. In most cases, reactions are minor and easy to treat. However, contact your healthcare provider if you have more serious problems with this vaccine, such as a high fever, a seizure, or difficulty breathing.

An Introduction to ProQuad Vaccine Side Effects

As with all vaccines, ProQuad® (MMRV) can cause side effects. However, not everyone who receives the vaccine will have problems. Most children tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with ProQuad. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of the ProQuad Vaccine

ProQuad has been studied extensively in clinical trials, during which possible side effects were carefully documented. In addition, side effects reported during actual use of the vaccine after it was approved have been documented.
Based on this information, the most common ProQuad side effects include but are not limited to:
  • Pain, tenderness, or soreness at the injection site -- in up to 41.1 percent of children
  • Fever -- up to 21.5 percent
  • Redness at the injection site -- up to 24.4 percent
  • Swelling at the injection site -- up to 15.6 percent
  • Irritability -- up to 6.7 percent
  • A measles-like rash -- up to 5.1 percent
  • Bruising at the injection site -- up to 3.5 percent
  • A chickenpox-like rash -- up to 2.1 percent
  • A rash just at the injection site -- up to 2 percent.
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ProQuad Vaccine Information

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