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Rotarix Drug Interactions

There are a number of medications that could interact with Rotarix. For example, problems may occur if the oral vaccine is taken while you are also taking immune globulins or immunosuppressant medicines (such as corticosteroids, sirolimus, and chemotherapy). These interactions may decrease the effectiveness of the vaccine.

An Overview of Rotarix Interactions

In March 2010, the United States Food and Drug Administration (FDA) recommended that this vaccine should not be used, at least temporarily, since DNA from porcine circovirus type 1 (PCV1) has been found in the vaccine. This means that DNA from a virus found in pigs has been found in the vaccine. However, in May 2010, the FDA announced that it is safe to begin using Rotarix again, since PCV1 poses no known health risks to humans.
Rotarix® (rotavirus vaccine) can potentially interact with a few medications. Some of the medicines that may lead to interactions with Rotarix include:
  • Immune globulins
  • Immunosuppressants, such as:


    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)



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Rotarix Vaccine Information

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