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Drug Interactions With the Varicella Vaccine

Varicella Vaccine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when the varicella vaccine is combined with any of the drugs listed above.
Caution should be taken when giving intramuscular injections (including the varicella vaccine) to individuals taking anticoagulant medications (commonly known as "blood thinners"). Make sure your healthcare providers (including the nurse giving the vaccine) know if you or your child is taking an anticoagulant.
Immune Globulins or Blood Products
Immune globulins and blood products (such as blood or plasma transfusions) decrease the effectiveness of live vaccines (like the varicella vaccine). Vaccination with the varicella vaccine should be postponed for five months after a dose of immune globulin.
Immune globulins should not be given for two months after a dose of the varicella vaccine, unless the potential benefits of the immune globulin outweigh the benefit of vaccination.
If you are taking an immunosuppressant, you may not receive the full benefit of the varicella vaccine. More importantly, with live vaccines (such as the varicella vaccine), people taking immunosuppressants may be at a higher risk of actually developing the infection (usually a mild form) from the vaccine. In many situations, the varicella vaccine may not be recommended for people taking immunosuppressants.
People should avoid taking any salicylates (including aspirin) for six weeks after receiving the varicella vaccine, due to the potential risk of Reye's syndrome (a potentially fatal condition). This interaction is theoretical, based on cases of Reye's syndrome seen when people with chickenpox took aspirin.
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Varicella Vaccine Information

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