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Zinc Oxide Drug Interactions

Although there are no known drug interactions with using zinc oxide in the form of skin creams and ointments, there are possible drug interactions that may occur if you take zinc oxide in the form of oral supplements. Among the medications that may negatively interact with zinc oxide include cisplatin, penicillamine, and tetracycline antibiotics. Some of these drug interactions with zinc oxide may prevent certain medications from being absorbed into the bloodstream.

An Overview of Zinc Oxide Interactions

When taken by mouth, zinc oxide can potentially interact with other medications. Zinc oxide skin preparations (such as diaper rash cream and sunscreens) are not likely to interact with any medications. Some of these medicines that may lead to zinc oxide drug interactions include:
  • Cisplatin
  • Fluoroquinolone antibiotics, including (but not limited to):



  • Penicillamine (Cuprimine®, Depen®)
  • Tetracycline antibiotics, such as:



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Zinc Oxide Ointment Information

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